Search results for " binding ability"

showing 2 items of 2 documents

Host—Guest Interactions Involving Cyclodextrins: Useful Complementary Insights Achieved by Polarimetry.

2007

Abstract By means of simple polarimetry, we studied the binding abilities of native α-, β-, and γ-cyclodextrins toward a group of suitably chosen model guests. We were able to get reliable estimations of the binding constants K, spread over a wide range (from 3.7 to 12,300 M−1), allowing us to carry on interesting comparisons. A comprehensive discussion of polarimetric data, and in particular a detailed analysis of the variations ΔΘ of molar optical activities consequent to inclusion, offered us the opportunity to get useful insights into the structure and dynamic behavior of host–guest complexes.

ChemistryOrganic ChemistryDrug DiscoveryPolarimetryOrganic chemistrycyclodextrin binding abilityHost-guest interactionSettore CHIM/06 - Chimica OrganicaGeneral MedicineHost-guest interactions; cyclodextrin binding abilityBiological systemBiochemistryHost (network)ChemInform
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A spectrofluorimetric study of binary fluorophore-cyclodextrin complexes used as chiral selectors

2005

Abstract Six binary complexes between three fluorophores (pyrene, xanthone and anthraquinone) and β-cyclodextrin (β-CD) or heptakis-(6-amino)-(6-deoxy)-β-cyclodextrin (am-β-CD) were tested at two pH values (8.0 and 9.0) as chiral selectors for three α-amino acids chosen as model. The conditional constant (β2T) values for ternary complexes (fluorophore-CD-amino acid), determined by means of fluorescence spectroscopy, showed that the binary complexes are suitable receptors for chiral recognition. The effect of α-amino acids on stability and stoichiometric ratio of the binary complexes has also been studied. The binary complexes were in most cases stabilized by adding the ternary agent. The tr…

chemistry.chemical_classificationFluorophoreCyclodextrinChemistryOrganic ChemistrySettore CHIM/06 - Chimica OrganicaBiochemistryFluorescenceAnthraquinoneFluorescence spectroscopychemistry.chemical_compoundDrug DiscoveryXanthonePhysical chemistryPyreneOrganic chemistrycyclodextrin binding abilityTernary operation
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